The conserved family of Transmembrane channel-like (TMC) proteins has attracted significant interest since two members appear to be key components of the mammalian hair cell mechanotransducer involved in hearing. expresses two TMC proteins, TMC-1 and TMC-2. TMC-1 is widely expressed in in both muscles and the nervous system. This wide expression pattern suggests that TMC-1 might serve different functions in the various neurons. TMC-1 has previously been shown to function in neurons, playing a role in chemosensation in the ASH neurons and mechanosensation in OLQ neurons, further supporting this hypothesis. is expressed in the high-threshold mechanosensory neuron, ALA. We show that mutants show defects in the ALA-dependent inhibition of egg-laying in response to a harsh mechanical stimulus.
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| http://dx.doi.org/10.17912/micropub.biology.000439 | DOI Listing |
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