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Conjugate Position of Glucuronide and Sulfate in Piceatannol Derivatives Affects the Stability and Hydrolytic Resistance of the Conjugate in Biological Matrices.
J Agric Food Chem
December 2024
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu-shi, Toyama 939-0398, Japan.
Piceatannol, a stilbene compound, undergoes a comprehensive phase II metabolism mediated by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in humans. Despite their well-documented beneficial effects on health, their detailed pharmacokinetic fate, including the metabolite structure and properties, is poorly understood. Thus, we determined the structure of seven glucuronides and six sulfates transformed from piceatannol and its methylated derivatives in recombinant yeast cells expressing UGTs or SULTs.
View Article and Find Full Text PDFDevelopment of a large-scale medical visual question-answering dataset.
Commun Med (Lond)
December 2024
Shanghai Jiao Tong University, Shanghai, China.
Background: Medical Visual Question Answering (MedVQA) enhances diagnostic accuracy and healthcare delivery by leveraging artificial intelligence to interpret medical images. This study aims to redefine MedVQA as a generation task that mirrors human-machine interaction and to develop a model capable of integrating complex visual and textual information.
Methods: We constructed a large-scale medical visual-question answering dataset, PMC-VQA, containing 227,000 VQA pairs across 149,000 images that span various modalities and diseases.
Prognostic factors in patients with gastrointestinal perforation under the acute care surgery model : a retrospective cohort study.
BMC Surg
December 2024
Department of Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Background: Gastrointestinal perforation (GIP) is a life-threatening condition that necessitates immediate surgical intervention. This study aims to identify prognostic factors in patients with GIP treated within a standardized acute care surgery (ACS) framework.
Materials And Methods: This single center retrospective cohort study analyzed patients diagnosed with GIP who underwent emergent surgery and were admitted to the intensive care unit between January 2013 and March 2023.
Development and validation of a multiplex chip-based droplet digital PCR method for detecting CNVs in 7q11.2 and 22q11.2 regions.
Clin Chim Acta
December 2024
Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Center of Laboratory Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Copy number variations (CNVs) in the 7q11.2 and 22q11.2 chromosomal regions are major contributors to genetic disorders such as Williams-Beuren syndrome and 22q11.
View Article and Find Full Text PDFA review of deep learning models for the prediction of chromatin interactions with DNA and epigenomic profiles.
Brief Bioinform
November 2024
Agricultural Bioinformatics Key Laboratory of Hubei Province, Huazhong Agricultural University, No. 1 Shizishan Street, Hongshan District, Wuhan 430070, China.
Advances in three-dimensional (3D) genomics have revealed the spatial characteristics of chromatin interactions in gene expression regulation, which is crucial for understanding molecular mechanisms in biological processes. High-throughput technologies like ChIA-PET, Hi-C, and their derivatives methods have greatly enhanced our knowledge of 3D chromatin architecture. However, the chromatin interaction mechanisms remain largely unexplored.
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