We present a case of transfusion-related acute lung injury as a complication of convalescent plasma transfusion in a patient who presented with COVID-19-related severe acute respiratory syndrome. Despite treatment with tocilizumab, remdesivir, and intravenous steroids, worsening dyspnea prompted adjunctive treatment with convalescent plasma. Two hours after completion of the plasma transfusion, the patient developed hypoxia-induced cardiac arrest secondary to transfusion-related acute lung injury. This case sheds light on life-threatening transfusion reactions and emphasizes the need to investigate post-transfusion monitoring protocols as well as the possible role of surveillance equipment.
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| http://dx.doi.org/10.1177/03000605211032814 | DOI Listing |
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Article Synopsis
- Transfusion-related acute lung injury (TRALI) is a serious and often overlooked complication of blood transfusions, particularly in intensive care settings, contributing significantly to transfusion-related mortality.
- The review highlights important aspects of TRALI's pathophysiology, emphasizing the role of complement activation and the involvement of immune cells like neutrophils and macrophages, as well as the pulmonary endothelium.
- It calls for better reporting of TRALI cases and further research to identify biomarkers and potential therapies, suggesting that interleukin-10, complement inhibition, and Osteopontin blockade could be promising strategies, with a need for future clinical trials.
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