Many species from the genus are used in traditional medicine and contain polymethoxylated flavonoids. These compounds show anti-inflammatory and chemopreventive activities, among others, and therefore have a big potential to be developed as therapeutic agents or dietary supplements. species are different in their profile and yield of polymethoxylated flavonoids. Therefore, polymethoxylated flavonoids were identified and quantified in seven different species, including wild-type and commercially available species. All species were profiled using UPLC-QTOF-MS/MS analysis combined with mass spectral molecular networking. A total of 38 polymethoxylated flavonoids were detected and 8 of them were present in every species. As the yield of polymethoxylated flavonoids was different for each species, a generally applicable HPLC-diode array detection method was developed and validated according to the ICH guidelines to quantify the amount of nobiletin and the total amount of polymethoxylated flavonoids expressed as nobiletin. Analysis of the seven samples showed evidence that wild-type species (e.g., ) contain higher yields of polymethoxylated flavonoids compared to commercially available species (e.g., ). Qualitative analysis revealed the broadest variety of different PMFs in , and × , which makes them interesting sources of polymethoxylated flavonoids for future development as therapeutic agents or dietary supplements.
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Article Synopsis
- Citrus peels contain a variety of polymethoxylated flavones (PMFs) known for their health benefits and pharmacological properties.
- An analysis of 27 Citrus varieties revealed that mandarin peels had the most diverse and highest levels of PMFs, with specific varieties demonstrating strong antioxidant and enzyme inhibitory effects.
- The study highlights the health-promoting potential of different citrus species, paving the way for future breeding programs to enhance PMF content for better health outcomes.
Nobiletin protects against alcohol-induced mitochondrial dysfunction and liver injury by regulating the hepatic NRF1-TFAM signaling pathway.
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December 2024
Department of Nutrition, Zhejiang Hospital, Hangzhou, People's Republic of China.
Objectives: Alcohol and its metabolites, such as acetaldehyde, induced hepatic mitochondrial dysfunction play a pathological role in the development of alcohol-related liver disease (ALD).
Methods: In this study, we investigated the potential of nobiletin (NOB), a polymethoxylated flavone, to counter alcohol-induced mitochondrial dysfunction and liver injury.
Results: Our findings demonstrate that NOB administration markedly attenuated alcohol-induced hepatic steatosis, endoplasmic reticulum stress, inflammation, and tissue damage in mice.
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