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The role of spinal cord extrasynaptic α GABA receptors in chronic pain. | LitMetric

AI Article Synopsis

Article Abstract

Chronic pain is an incapacitating condition that affects a large population worldwide. Until now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition mediated by GABA receptors (GABA R) is considered a relevant factor in mediating chronic pain. Even though both synaptic and extrasynaptic GABA inhibition are present in neurons that process nociceptive information, the latter is not considered relevant as a target for the development of pain treatments. In particular, the extrasynaptic α GABA Rs are expressed in laminae I-II of the spinal cord neurons, sensory neurons, and motoneurons. In this review, we discuss evidence showing that blockade of the extrasynaptic α GABA Rs reduces mechanical allodynia in various models of chronic pain and restores the associated loss of rate-dependent depression of the Hoffmann reflex. Furthermore, in healthy animals, extrasynaptic α GABA R blockade induces both allodynia and hyperalgesia. These results indicate that this receptor may have an antinociceptive and pronociceptive role in healthy and chronic pain-affected animals, respectively. We propose a hypothesis to explain the relevant role of the extrasynaptic α GABA Rs in the processing of nociceptive information. The data discussed here strongly suggest that this receptor could be a valid pharmacological target to treat chronic pain states.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374381PMC
http://dx.doi.org/10.14814/phy2.14984DOI Listing

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