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Mortality after concurrent treatment with gabapentin and opioids in older adults with spine diagnoses.
Pain
October 2024
Clinical Learning, Evidence, and Research Center, University of Washington, Seattle, WA, United States.
Article Synopsis
- The study investigates the effects of using gabapentin alongside opioids compared to tricyclic antidepressants (TCAs) or duloxetine with opioids in older adults with spine-related issues.
- Researchers analyzed data from 134,266 Medicare beneficiaries, focusing on mortality rates and major medical complications from 2017 to 2019.
- They found no significant difference in mortality between the two groups, but those on gabapentin and opioids had a slightly higher risk of major medical complications.
Efficacy and safety of subcutaneous injection of botulinum toxin in the treatment of Chinese postherpetic neuralgia compared to analgesics: a systematic review of randomized controlled trials and meta-analysis.
Front Neurol
October 2024
Department of Geriatrics, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.
Objective: The purpose of this meta-analysis is to investigate the efficacy and safety of a subcutaneous injection of botulinum toxin in the treatment of postherpetic neuralgia (PHN) compared to analgesics.
Methods: We searched PubMed, Cochrane Library, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang for randomized controlled trials (RCTs) from inception to 10 September 2023. The primary clinical outcomes included visual analog scale (VAS) pain scores and clinical effective rates.
Neuropharmacology of Neuropathic Pain: A Systematic Review.
Cureus
September 2024
Cardiology/Global Clinical Scholars Research Training, Harvard Medical School, Boston, USA.
Article Synopsis
- * A review of various studies found that gabapentinoids (like gabapentin and pregabalin) and tricyclic antidepressants (like amitriptyline) are effective for managing neuropathic pain by targeting neurotransmitters.
- * While selective serotonin reuptake inhibitors (SSRIs) are less effective for this type of pain, cannabinoids showed promise with mild side effects; opioids are generally a last resort due to their risks.
Relieving postherpetic neuralgia pain via gabapentin-loaded bigels as an auspicious topical drug delivery system.
Daru
December 2024
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Background: Over the past decades, a substantial portion of the population worldwide has been infected with varicella zoster and most cases developed shingles. Unfortunately, shingles is usually accompanied by postherpetic neuralgia, which may persist for months to years after the resolution of the viral infection.
Objectives: Gabapentin is an orally gamma-aminobutyric acid analogue approved by the Food and Drug Administration to manage shingles postherpetic neuralgia.
L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat.
Biomolecules
August 2024
Physiology Department, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Introduction: L. (CSL) extract has pain-relieving potential due to its cannabinoid content, so the effects of two CSL extracts on alleviating neuropathic pain were investigated in vivo. Methods and groups: Male Wistar rats (n = 130) were divided into groups and received vincristine (0.
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