AI Article Synopsis
- Recent findings indicate that beta-adrenergic receptors (β-ARs) play a more significant role in facilitating long-term synaptic changes in the ventral hippocampus compared to the dorsal hippocampus.
- Activation of β-ARs with isoproterenol specifically enhances output in the dorsal hippocampus within the 3-40 Hz frequency range without impacting short-term synaptic changes.
- The study suggests that β-AR modulation influences short-term neuronal activity differently along the length of the hippocampus, highlighting functional specialization in this brain region.
Article Abstract
Recent evidence shows a greater facilitating effect of beta-adrenergic receptors (β-ARs) on long-term synaptic plasticity in the ventral versus the dorsal hippocampus. Here, using field potentials from the CA1 area and a ten-pulse stimulation train of varying frequency we show that activation of β-ARs by isoproterenol preferentially facilitates the output from the dorsal hippocampus at the frequency range of 3-40 Hz without affecting short-term synaptic plasticity. Furthermore, isoproterenol increases basal synaptic transmission in the dorsal hippocampus only and enhances basal neuronal excitation more in the dorsal than the ventral hippocampus. These results suggest that β-AR-modulation of short-term neuronal dynamics differs along the longitudinal axis of the hippocampus, thereby contributing to functional specialization along the same axis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363828 | PMC |
| http://dx.doi.org/10.1016/j.ibneur.2021.07.002 | DOI Listing |
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