AI Article Synopsis
- Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic skin conditions, and understanding their link can help with treatment and understanding their causes.
- A study at Duke University examined 28,780 patients with AD and found a significant association with HS, showing AD patients are 5.57 times more likely to have HS than those without AD.
- The study, while revealing important correlations, had limitations due to its retrospective nature and being conducted in a single institution, highlighting the need for more research.
Article Abstract
Background: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatment.
Objective: To investigate the association between AD and HS.
Methods: We performed a retrospective cohort study of patients seen at Duke University Medical Center from 2007 to 2017 who had AD compared with a control group without an AD diagnosis. The association of AD and HS was evaluated using a logistic regression model after adjusting for other confounders including age, sex, and race.
Results: Of 28,780 patients with an AD diagnosis, 325 (1.1%) were diagnosed with HS compared with 76 (0.2%) within the 48,383 patients in the non-AD group. An adjusted logistic regression model demonstrated an increased odds ratio of having HS diagnosis in the AD group as compared with the control non-AD group (odds ratio: 5.57, 95% confidence interval: 4.30-7.21, < .001).
Limitations: This was a retrospective study performed at a single institution with the possibility of surveillance bias being present.
Conclusions: Patients with AD are more likely to be diagnosed with HS than patients without AD. Further research is needed to understand the pathophysiologic mechanism and potential treatment implications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362302 | PMC |
| http://dx.doi.org/10.1016/j.jdin.2021.04.006 | DOI Listing |
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