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Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study. | LitMetric

AI Article Synopsis

  • A study looked at how certain measurements from PET scans can help predict how long patients with a type of blood cancer called diffuse large B-cell lymphoma will survive without their disease getting worse.
  • It found that larger tumor volumes and glycolysis (how tumors use sugar) were linked to shorter survival times, even after considering other health factors.
  • The results showed that these measurements can help doctors identify which patients are at higher risk, but another measurement called maximum standardized uptake value didn’t provide useful information.

Article Abstract

This retrospective analysis of the phase III GOYA study investigated the prognostic value of baseline metabolic tumor volume parameters and maximum standardized uptake values for overall and progression-free survival (PFS) in treatment-naïve diffuse large B-cell lymphoma. Baseline total metabolic tumor volume (determined for tumors >1 mL using a threshold of 1.5 times the mean liver standardized uptake value +2 standard deviations), total lesion glycolysis, and maximum standardized uptake value positron emission tomography data were dichotomized based on receiver operating characteristic analysis and divided into quartiles by baseline population distribution. Of 1,418 enrolled patients, 1,305 had a baseline positron emission tomography scan with detectable lesions. Optimal cut-offs were 366 cm3 for total metabolic tumor volume and 3,004 g for total lesion glycolysis. High total metabolic tumor volume and total lesion glycolysis predicted poorer PFS, with associations retained after adjustment for baseline and disease characteristics (high total metabolic tumor volume hazard ratio: 1.71, 95% confidence interval [CI]: 1.35- 2.18; total lesion glycolysis hazard ratio: 1.46; 95% CI: 1.15-1.86). Total metabolic tumor volume was prognostic for PFS in subgroups with International Prognostic Index scores 0-2 and 3-5, and those with different cell-of-origin subtypes. Maximum standardized uptake value had no prognostic value in this setting. High total metabolic tumor volume associated with high International Prognostic Index or non-germinal center B-cell classification identified the highest-risk cohort for unfavorable prognosis. In conclusion, baseline total metabolic tumor volume and total lesion glycolysis are independent predictors of PFS in patients with diffuse large B-cell lymphoma after first-line immunochemotherapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244811PMC
http://dx.doi.org/10.3324/haematol.2021.278663DOI Listing

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