endocarditis is a fatal complication and the most frequent cause of death for human brucellosis. This study aimed to systematically review the literature on the follow-up outcomes of endocarditis and analyze the determinants affecting the follow-up outcomes. The databases PubMed, Web of Science, Embase, and Cochrane were searched using keywords and suitable combinations. All studies reporting the follow-up outcomes of endocarditis were included. Finally, a total of 76 studies (207 patients), including cases or case series, were included. The event rate for patients who underwent short- and long-term follow-up was 12.0% (2 relapsed and 1 died) and 8.1% (6 relapsed and 8 died), respectively. The differences in outcomes between different age groups (18-39, 40-59, and ≥60) were significant ( < 0.05, = 0.035). The outcomes of the 18-39 age group were worse than those of the 40-59 age group (OR, 0.277; 95% CI, 0.103-0.748; = 0.011). Accordingly, follow-up (both short- and long-term follow-up) is essential for endocarditis patients, especially for younger patients (18-39 years) in the first 6 months after treatment. The burden of endocarditis related complications were immense. Further studies are needed to explore age-based epidemiology of endocarditis and the exact influencing factors of the follow-up outcomes.
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| http://dx.doi.org/10.1080/21655979.2021.1962683 | DOI Listing |
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