Subspace-based predictive control of Parkinson's disease: A model-based study.

Deep brain stimulation (DBS) of the Basal Ganglia (BG) is an effective treatment to suppress the symptoms of Parkinson's disease (PD). Using a closed-loop scheme in DBS can not only improve its therapeutic effects but it can also reduce its energy consumption and possible side effects. In this paper, a predictive closed loop control strategy is employed to suppress the PD in real-time. A linear multi-input multi-output (MIMO) state-delayed system is considered as a simplified model of the BG neuronal network relating the stimulation signals as inputs to the beta power of local field potentials as PD biomarkers. The effect of time delay in different areas of the BG is incorporated into this model and a real-time subspace-based identification is implemented to continuously model the state of the BG neuronal network and drive the predictive control strategy. Simulation results show that the proposed MIMO subspace based predictive controller can suppress PD symptoms more effectively and with less power consumption compared to the conventional open-loop DBS and a recently proposed single-input single-output closed loop controller.