DISCO is key to successful centriole maturation.

J Cell Biol

Université de Paris, Centre national de la recherche scientifique, Institut Jacques Monod, Paris, France.

Published: September 2021

Centriole maturation is essential for ciliogenesis, but which proteins and how they regulate ciliary assembly is unclear. In this issue, Kumar et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202011133) shed light on this process by identifying a ciliopathy complex at the distal mother centriole that restrains centriole length and supports the formation of distal appendages.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374877PMC
http://dx.doi.org/10.1083/jcb.202107033DOI Listing

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