AI Article Synopsis
- The study investigates how extracellular vesicles (EVs) influence the growth and hormone production in bovine ovarian cortical stromal cells in a lab setting.
- The research found that EVs from bovine follicular fluid significantly enhance the production of steroid hormones like androstenedione and progesterone, especially at a concentration of 100 μg/ml.
- The findings are important for understanding how these vesicles contribute to ovarian development and the interplay between different cell types in the ovaries.
Article Abstract
The aim of this study was to investigate the effects of extracellular vesicles (EVs) on the proliferation and steroid hormone synthesis of bovine ovarian cortical stromal cells in vitro. The release and uptake of EVs are the new mechanisms of cell-to-cell communication. Using reverse transcriptase polymerase chain reaction, enzyme-linked immunosorbent assay, TUNEL and other experiments, we found that EVs in bovine follicular fluid can promote the proliferation and synthesis of androstenedione and progesterone in ovarian cortical stromal cells. Moreover, 100 μg/ml EVs caused the most significant effect. We conclude that EVs at 100 μg/ml can significantly promote the proliferation and synthesis of androstenedione and progesterone in ovarian cortical stromal cells. This research is of great significance for further elucidating the regulatory role of follicular fluid EVs in follicular development and atresia and for research on the interaction of ovarian stromal cells, granulosa cells and oocytes.
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| http://dx.doi.org/10.1111/rda.14007 | DOI Listing |
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