Chinese materia medica( CMM) serves as an important cornerstone for the development of traditional Chinese medicine( TCM) culture and industry due to its unique ecological,medical,economic,scientific and technological,and cultural values. The supply shortage and unstable quality of some CMM resources have hindered the development of TCM. Ensuring the sustainable use of CMM resources has become essential for the development of TCM in China. Enriching CMM resources is the key to ensuring the sustainable utilization of TCM resources in China,which can be achieved via expanding the medicinal parts,developing the substitutes,seeking for analogues,exploring the ethnic and folk medicines,or introducing foreign medicinal materials. CMM efficacy or function positioning plays a very important role in the transformation of new CMM resources. The strategies and methods for efficacy or function positioning of new CMM resources,including analogy,plant genetic relationship exploration,medicinal property deduction,ethnobotanical investigation,text mining,network pharmacology,and structure-activity relationship exploration,were systematically proposed in this study based on CMM theory,textual research,and modern methodologies. This paper is expected to provide a theoretical reference for the continuous enrichment and development of CMM resources and the high-quality development of TCM culture and industry.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20210502.102 | DOI Listing |
BMC Public Health
January 2025
Indian Council of Medical Research, New Delhi, India.
Background: Cardiometabolic multimorbidity (CMM), characterized by the coexistence of diabetes, hypertension, and cardiovascular disease, poses a major health challenge in India, particularly in rural areas with limited healthcare resources. Lifestyle interventions can manage cardiometabolic risk factors, yet adherence remains suboptimal. Mobile health (mHealth) interventions offer a scalable approach for managing CMM by promoting behaviour change and medication adherence.
View Article and Find Full Text PDFCurr Med Mycol
May 2024
Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
Zhongguo Zhong Yao Za Zhi
September 2024
School of Biological Science and Technology, University of Jinan Ji'nan 250022, China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Intercropping is a traditional and widely used planting pattern, and different intercropped plants have differences in spatial distribution and morphological structure compared with monoculture. Therefore, intercropping can realize efficient acquisition of limited space resources and efficient conversion of existing resources by utilizing the principle of niche complementarity of composite groups, weakening interspecific or intra-specific competition, and enhancing their complementary growth. Intercropping of Chinese medicinal material(CMM) has experienced the evolution of more than two thousand years from its founding to inheritance and development.
View Article and Find Full Text PDFBioorg Chem
December 2024
College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. Electronic address:
Due to the multifactorial nature of Alzheimer's disease (AD), effective multi-targeted directed ligands (MTDLs) are urgently needed for its treatment as single-target drugs currently encounter therapeutic challenges. Two series of new 4-aminoquinoline derivatives containing an amine or hydroxamic acid terminal were designed, synthesized and evaluated for their cholinesterase inhibition, antioxidant and metal-ion chelation properties. Among them, hydroxamic acid-containing compounds 7r and 7f exhibited the best inhibitor activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), respectively, with the corresponding IC values of 0.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
December 2024
Department of Internal Medicine B, University Hospital Münster, Münster, Germany.
Background: It has been shown that in patients with liver cirrhosis, sarcopenia is a predictor of acute decompensation (AD), acute-on-chronic liver failure (ACLF) and death. However, computer tomography (CT), as a suggested standard method for diagnosing sarcopenia, is resource intensive and involves radiation exposure. Therefore, in this study, we evaluate the muscle thickness of quadriceps femoris measured by ultrasound (US) as a prognostic parameter for AD and all-cause mortality in chronic liver disease.
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