Stem cell-like memory T cells: The generation and application.

J Leukoc Biol

Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.

Published: December 2021

Stem cell-like memory T cells (Tscm), are a newly defined memory T cell subset with characteristics of long life span, consistent self-renewing, rapid differentiation into effector T cells, and apoptosis resistance. These features indicate that Tscm have great therapeutic or preventive purposes, including being applied in chimeric Ag receptor-engineered T cells, TCR gene-modified T cells, and vaccines. However, the little knowledge about Tscm development restrains their applications. Strength and duration of TCR signaling, cytokines and metabolism in the T cells during activation all influence the Tscm development via regulating transcriptional factors and cell signaling pathways. Here, we summarize the molecular and cellular pathways involving Tscm differentiation, and its clinical application for cancer immunotherapy and prevention.

Download full-text PDF

Source
http://dx.doi.org/10.1002/JLB.5MR0321-145RDOI Listing

Publication Analysis

Top Keywords

stem cell-like
8
cell-like memory
8
memory cells
8
tscm development
8
cells
6
tscm
5
cells generation
4
generation application
4
application stem
4
cells tscm
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!