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Comparative Analysis of Active LTR Retrotransposons in Sunflower ( L.): From Extrachromosomal Circular DNA Detection to Protein Structure Prediction.
Int J Mol Sci
December 2024
All-Russia Research Institute of Agricultural Biotechnology, Timiryazevskaya Str. 42, 127550 Moscow, Russia.
Plant genomes possess numerous transposable element (TE) insertions that have occurred during evolution. Most TEs are silenced or diverged; therefore, they lose their ability to encode proteins and are transposed in the genome. Knowledge of active plant TEs and TE-encoded proteins essential for transposition and evasion of plant cell transposon silencing mechanisms remains limited.
View Article and Find Full Text PDFDeveloping a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir.
NPJ Antimicrob Resist
December 2024
Biocomplexity Institute, University of Virginia, Charlottesville, VA USA.
Mobile genetic elements are key to the global emergence of antibiotic resistance. We successfully reconstructed the complete bacterial genome and plasmid assemblies of isolates sharing the same carbapenemase gene to understand evolution over time in six confined hospital drains over five years. From 82 isolates we identified 14 unique strains from 10 species with 113 carrying plasmids across 16 distinct replicon types.
View Article and Find Full Text PDFThe chromatin remodeling factor OsINO80 promotes H3K27me3 and H3K9me2 deposition and maintains TE silencing in rice.
Nat Commun
December 2024
State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
The INO80 chromatin remodeling complex plays a critical role in shaping the dynamic chromatin environment. The diverse functions of the evolutionarily conserved INO80 complex have been widely reported. However, the role of INO80 in modulating the histone variant H2A.
View Article and Find Full Text PDFEmergence and genetic characterization of KLUC-3 extended-spectrum β-lactamase-producing Escherichia coli ST95 High-Risk clone causing nosocomial infection in Japan.
J Glob Antimicrob Resist
December 2024
Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Objectives: KLUC β-lactamase is a minor extended-spectrum β-lactamase (ESBL) derived from chromosome-encoded cefotaximase in Kluyvera cryocrescens. This study aimed to characterize the genetic context of KLUC-3-producing Escherichia coli and bla-harboring plasmids and assess nosocomial transmission.
Methods: In a national genomic surveillance conducted in 2019 and 2020, KLUC-3-producing E.
Adverse Obstetric Outcomes in Pregnancies With Major Fetal Congenital Heart Defects.
JAMA Pediatr
December 2024
Center for Fetal Medicine and Pregnancy, Department of Gynecology, Fertility, and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Article Synopsis
- Understanding the risk profile of obstetric complications in pregnancies with fetal major congenital heart defects (MCHDs) is essential for effective counseling and care.
- This cohort study analyzed data from over 534,000 pregnancies in Denmark between 2008 and 2018, focusing on the link between fetal MCHDs and adverse obstetric outcomes like preeclampsia and preterm birth.
- Results showed that pregnancies with fetal MCHDs had a significantly higher rate of adverse outcomes (22.8%) compared to those without MCHDs (9.0%), highlighting the increased risks associated with these conditions.
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