AI Article Synopsis
- Sedentary behavior is linked to various diseases, yet its molecular mechanisms remain unclear; this study explores biomarkers related to inflammation and immune response in patients post-ischemic stroke.
- A total of 257 participants were monitored for sedentary behavior using sensors and their blood samples were analyzed for multiple biomarkers, revealing significant associations with levels of hsCRP, IL-6, neopterin, and others.
- The findings suggest that the PAr-index, a marker of inflammation, may serve as a valuable predictive tool for future stroke risk and shows a complex relationship with sedentary behavior.
Article Abstract
Background: Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional and novel biomarkers of inflammation and immune modulation and their association to objectively measured sedentary behaviour in an ischemic stroke population.
Methods: Patients admitted to hospital with acute ischemic stroke were included in the multicentre Norwegian Cognitive Impairment After Stroke (Nor-COAST) study (n = 815). For this sub-study (n = 257), sedentary behaviour was registered 3 months after stroke using position transition data from the body-worn sensor, ActivPal®. Blood samples were analysed for high sensitive C-reactive protein (hsCRP), the cytokines interleukin-6 (IL-6) and 10 (IL-10), neopterin, tryptophan (Trp), kynurenine (kyn), kynurenic acid (KA), and three B6 vitamers, pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and pyridoxic acid (PA). The kynurenine/tryptophan ratio (KTR) and the pyridoxic acid ratio index (PAr = PA: PL + PLP) were calculated.
Results: Of the 815 patients included in the main study, 700 attended the three-month follow-up, and 257 fulfilled the inclusion criteria for this study. Sedentary time was significantly associated with levels of hsCRP, IL-6, neopterin, PAr-index, and KA adjusted for age, sex, waist circumference, and creatinine. In a fully adjusted model including all the significant biomarkers except hsCRP (because of missing values), sedentary time was independently positively associated with the PAr-index and negatively with KA. We did not find an association between sedentary behaviour, IL-10, and KTR.
Conclusions: The PAr-index is known to capture several modes of inflammation and has previously shown predictive abilities for future stroke. This novel result indicates that the PAr-index could be a useful biomarker in future studies on sedentary behaviour and disease progression. KA is an important modulator of inflammation, and this finding opens new and exciting pathways to understand the hazards of sedentary behaviour.
Trial Registration: The study was registered at Clinicaltrials.gov ( NCT02650531 ). First posted 08/01/2016.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365944 | PMC |
| http://dx.doi.org/10.1186/s12883-021-02343-0 | DOI Listing |
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