Background: Children with early language delays are at increased risk of persistent language impairment. Early identification and intervention are desirable. Parent-report inventories are useful screening tools, but the screening context places limits at their length. Validity of parent-report screening tools in languages other than English has been rarely reported in detail.
Aims: The aim was to establish the concurrent validity of an existing 40-item parent-report vocabulary screening tool in Czech, using a picture-based examiner-administered comprehension and production task as a concurrent measure of vocabulary.
Methods & Procedures: Parents of 200 children aged 1;3 to 3;6 were given the screening inventory, in which they were asked if their child says or comprehends each of 40 words. At the same time, children were administered a picture-based comprehension and production task. Concurrent validity of the inventory was examined using correlations, partial correlations, and regression analyses controlling for age.
Outcomes & Results: The partial Spearman correlation (controlling for age) between production scores from parent-report and production scores from the examiner-administered task was 0.53; for comprehension, the correlation between parent report and test scores was 0.36. These values are similar to those reported for short and full versions of MacArthur-Bates CDI for 2-year-olds.
Conclusion & Implications: A 40-item tool shows clear concurrent relations with an examiner-administered picture comprehension and production task. The study demonstrates that short parent-report tools may be useful in early identification of language impairments, and they may be a good option particularly in languages that have limited repertoire of assessment instruments.
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http://dx.doi.org/10.1016/j.jcomdis.2021.106146 | DOI Listing |
Toxicol Mech Methods
January 2025
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, India.
Endocrine-disrupting chemicals (EDCs) significantly contribute to health issues by interfering with hormonal functions. Bisphenol A (BPA), a prominent EDC, is extensively utilized as a monomer and plasticizer in producing polycarbonate plastic and epoxy resins, making it one of the highest-demanded chemicals in commercial use. This is the major component used in plastic products, including bottles, containers, storage items, and food serving ware.
View Article and Find Full Text PDFBMC Med Res Methodol
January 2025
School of Management, Beijing University of Chinese Medicine, Beijing, China.
Purpose: The process of searching for and selecting clinical evidence for systematic reviews (SRs) or clinical guidelines is essential for researchers in Traditional Chinese medicine (TCM). However, this process is often time-consuming and resource-intensive. In this study, we introduce a novel precision-preferred comprehensive information extraction and selection procedure to enhance both the efficiency and accuracy of evidence selection for TCM practitioners.
View Article and Find Full Text PDFJ Nat Med
January 2025
Chongqing Academy of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing, 402760, China.
Non-Hodgkin lymphomas (NHL), including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), and follicular lymphoma (FL), predominantly arise from B cells undergoing germinal center (GC) reactions. The transcriptional repressor B-cell lymphoma 6 (BCL6) is indispensable for GC formation and contributes to lymphomagenesis via its BTB domain-mediated suppression of target genes. Dysregulation of BCL6 underpins the pathogenesis of GC-derived NHL.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Botany, MMV, Banaras Hindu University, Varanasi, 221005, India.
The research highlights the importance of exploring endophytic microbiomes of medicinal plants to uncover their potential for secondary metabolite production and their role in the biosynthesis of host-derived compounds. This study was aimed to isolate leaf endophytic bacteria of Rauvolfia serpentina, investigate their antibacterial, antioxidant potentials and detect host-origin compound reserpine using Reverse Phase High-Performance Liquid Chromatography (RPHPLC). Untargeted analysis via Ultra High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry (UHPLC-HRMS/MS) was conducted for profiling main phytochemicals in the leaves and to explore potential bioactive compounds in bacterial extracts.
View Article and Find Full Text PDFSci Data
January 2025
Department of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea.
Chinese hamster ovary (CHO) cells play a pivotal role in the production of recombinant therapeutics. In the present study, we conducted a genome-scale pooled CRISPR knockout (KO) screening using a virus-free, recombinase-mediated cassette exchange-based platform in CHO-K1 host and CHO-K1 derived recombinant cells. Genome-wide guide RNA (gRNA) amplicon sequencing data were generated from cell libraries, as well as short- and long-term KO libraries, and validated through phenotypic assessment and gRNA read count distribution.
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