Objective: Previous investigations yielded inconsistent results for diagnostic and prognostic predictive values of MicroRNAs (miRNAs) for acute myocardial infarction (AMI).

Methods And Results: We systematically searched on PubMed and Web of Science for articles explored association of miRNAs and AMI published from January 1989 to March 2019. For diagnostic studies, a summary of sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratio (DOR), which indicated the accuracy of microRNAs in the differentiation of AMI and no AMI, were calculated from the true positive (TP), true negative (TN), false positive (FP), and false negative (FN) of each study. In addition, the summary receive-operating characteristics (SROC) curve was constructed to summarize the TP and FP rates. For follow-up study, we computed hazard ratios (HRs) and 95% confidence intervals (CIs) for individual clinical outcomes. The meta-analysis showed a sensitivity [0.72 (95% CI: 0.61--0.81)] and specificity [0.88 (95% CI: 0.79--0.94)] of miR-1 for AMI. In addition, miR-133 showed a sensitivity [0.73 (95% CI: 0.55--0.85)] and specificity [0.88 (95% CI: 0.74--0.95)] for AMI. Moreover, the present study showed a sensitivity [0.83 (95% CI: 0.74--0.89)] and specificity [0.96 (95% CI: 0.82--0.99)] of miR-208 for AMI. A significant association was found between miR-208 and mortality after AMI (HR 1.09, 95% CI 1.01--1.18). It also indicated a sensitivity [0.84 (95% CI: 0.70--0.92)] and specificity [0.97 (95% CI: 0.87--0.99)] of miR-499 for AMI.

Conclusions: Circulating miR-1, miR-133, miR-208, and miR-499 showed diagnostic values in AMI.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294880PMC
http://dx.doi.org/10.1097/MD.0000000000026627DOI Listing

Publication Analysis

Top Keywords

95%
10
diagnostic prognostic
8
prognostic predictive
8
predictive values
8
values micrornas
8
acute myocardial
8
myocardial infarction
8
ami
8
likelihood ratios
8
specificity [088
8

Similar Publications

Article Synopsis
  • The study measured fibrinogen fluorescence at temperatures between 20 and 80 degrees Celsius across different pH levels.
  • It was found that raising the temperature from 20 to 40 degrees Celsius did not change the structure of fibrinogen in solutions with pH between 4.5 and 9.3.
  • However, temperatures between 40 to 50 degrees Celsius caused some structural changes in neutral solutions, and temperatures above 50-55 degrees Celsius led to significant denaturation of the fibrinogen molecule.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!