AI Article Synopsis
- - Organ-on-chip (OoC) systems are advanced microfluidic models that replicate the structure and function of real organs better than traditional 2D models.
- - These systems hold promise for improving studies on drug efficacy and toxicity, leading to more relevant results for human health and disease mechanisms.
- - The article discusses current applications of OoCs and explores future possibilities for their use in drug discovery.
Article Abstract
Organ-on-chip (OoC) systems are in vitro microfluidic models that mimic the microstructures, functions and physiochemical environments of whole living organs more accurately than two-dimensional models. While still in their infancy, OoCs are expected to bring ground-breaking benefits to a myriad of applications, enabling more human-relevant candidate drug efficacy and toxicity studies, and providing greater insights into mechanisms of human disease. Here, we explore a selection of applications of OoC systems. The future directions and scope of implementing OoCs across the drug discovery process are also discussed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421049 | PMC |
| http://dx.doi.org/10.1042/BST20210840 | DOI Listing |
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