AI Article Synopsis
- Cardiovascular diseases pose significant risks to health, particularly emphasizing the concern over myocardial injury and the potential for new drug development through the unique properties of Chinese medicine.
- Recent advancements in isolating cardiomyocytes have led to the creation of cost-effective and controllable in vitro models that simulate cardiomyocyte injury, which are essential for understanding mechanisms and testing treatments.
- This study reviews various in vitro models representing diverse clinical conditions, assessing their principles, strengths, and challenges to support further exploration of myocardial injury and therapeutic options.
Article Abstract
Cardiovascular diseases seriously endanger human health and life. The accompanying myocardial injury has been a focus of attention in society. Chinese medicine,serving as a natural and precious reservoir for the research and development of new drugs,is advantageous in resisting myocardial injury due to its multi-component,multi-pathway,and multi-target characteristics. In recent years,with the extensive application of culture method for isolated cardiomyocytes,a cost-effective,controllable in vitro model of cardiomyocyte injury with uniform samples is becoming a key tool for mechanism research on cardiomyocyte injury and drug development.A good in vitro model can reduce experimental and manpower cost,and also accurately stimulate clinical changes to reveal the mechanism. Therefore,the selection and establishment of in vitro model are crucial for the in-depth research. This study summarized the modeling principles,evaluation indicators,and application of more than ten models reflecting different clinical conditions,such as injuries induced by hypoxia-reoxygenation,hypertrophy,oxidative stress,inflammation,internal environmental disturbance,and toxicity. Furthermore,we analyzed advantages and technical difficulties,aiming to provide a reference for in-depth research on myocardial injury mechanism and drug development.
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| http://dx.doi.org/10.19540/j.cnki.cjcmm.20210311.601 | DOI Listing |
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