AI Article Synopsis
- * Scientists used a special test called flow cytometry to check for cancer cells in the fluid around the spine, which is called cerebrospinal fluid (CSF).
- * In a study, they found that this test was better at detecting cancer cells in infants than older methods, but more research is needed to see if it can help predict patient outcomes.
Article Abstract
Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78·6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL.
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| http://dx.doi.org/10.1111/bjh.17769 | DOI Listing |
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