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| http://dx.doi.org/10.1016/j.jaccao.2021.04.009 | DOI Listing |
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A Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of intravenous prasinezumab in early-stage Parkinson's disease (PADOVA): Rationale, design, and baseline data.
Parkinsonism Relat Disord
December 2024
Roche Pharma Research and Early Development (pRED), Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Introduction: Prasinezumab was shown to potentially delay motor progression in individuals with early-stage Parkinson's disease (PD) who were either treatment-naïve or on monoamine oxidase type B inhibitor (MAO-Bi) therapy in the PASADENA study. We report the rationale, design, and baseline patient characteristics of the PADOVA study, designed to evaluate prasinezumab in an early-stage PD population receiving standard-of-care (SOC) symptomatic medications.
Methods: PADOVA (NCT04777331) is a Phase 2b, multicenter, randomized, double-blind, placebo-controlled, parallel-group study, in which individuals with early-stage PD on SOC stable symptomatic monotherapy (levodopa or MAO-Bi) receive intravenous prasinezumab 1500 mg every 4 weeks.
An experimental study on water purification performance of modified volcanic rock ecological concrete.
Sci Rep
January 2025
Institute of International Rivers and Eco-Security, Yunnan University, Kunming, 650500, China.
Eco-concrete is an engineered porous material, often used in pervious pavement and slope protection. Volcanic rock, due to its loose and porous structure, can absorb pollutants and improve the performance of eco-concrete. Here, this study determined the performance of eco-concrete modified with different contents of volcanic rock in sewage purification.
View Article and Find Full Text PDFMethods for improving the thermal performance of thermal bridges of lightweight steel-framed buildings.
PLoS One
December 2024
School of Architecture and Civil Engineering, Xihua University, Chengdu, China.
The existence of a large number of thermal bridges in the Lightweight Steel-Framed (LSF) building leads to its energy loss. The reduction of the heat transfer of thermal bridges is crucial for increasing the thermal performance of the building envelope. In this study, the infrared technology was first used to measure the temperature of LSF buildings, and clear thermal bridge junctions were determined.
View Article and Find Full Text PDFUnveiling the Beneficial Effects of N as a CO Impurity on Fluid-Rock Reactions during Carbon Sequestration in Carbonate Reservoir Aquifers: Challenging the Notion of Purer Is Always Better.
Environ Sci Technol
December 2024
Key Laboratory of Unconventional Oil & Gas Development (China University of Petroleum (East China)), Ministry of Education, Qingdao 266580, China.
Article Synopsis
- - CO-enhanced oil recovery (CO-EOR) has potential benefits for oil extraction, but its effectiveness is often hindered by the availability of pure CO sources and expensive carbon capture processes.
- - This study explores the use of flue gas, which contains CO and nitrogen (N), for enhancing oil recovery while also reducing carbon emissions and improving CO storage.
- - Results show that with at least 50% CO enrichment, adding N improves the dissolution on calcite surfaces and optimizes calcite wettability, leading to safer and more efficient CO storage while lowering costs associated with capture.
Black-carrot drink şalgam as a habitat for spoilage yeasts.
Fungal Biol
December 2024
Department of Food Engineering, Faculty of Engineering, Çukurova University, Adana, Turkey. Electronic address:
Şalgam is a traditional drink produced via the lactic-acid fermentation of vegetables (black carrot and turnip), sourdough, and bulgur flour; with rock salt also added. During storage, an additional yeast-mediated fermentation can occur, causing changes in organoleptic properties, as evidenced by the microbe-mediated release of gases. Here, we characterise şalgam as a microbial habitat, identify the yeasts that cause spoilage, and characterise yeast-induced changes of the şalgam.
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