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| http://dx.doi.org/10.1016/j.jaccao.2020.11.016 | DOI Listing |
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Long-term weight change and transition of metabolic health status in middle life and the risk of atrial fibrillation.
Heart Rhythm
March 2025
Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Background: The association of long-term weight change with atrial fibrillation (AF) risk remains controversial and evidence for the effect of metabolic health transition on AF is limited.
Objective: To evaluate the effects of body mass index (BMI) change and transition in BMI-metabolic health status on AF.
Methods: We conducted a prospective cohort study within UK Biobank.
Domestic water hardness, genetic risk, and distinct phenotypes of cardiovascular disease.
Environ Health
March 2025
Health Management Division, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China.
Aims: The study aimed to investigate the association between domestic water hardness and the incidence of AF and the interaction effects between water hardness and genetic susceptibility to incident AF risk. As a secondary objective, its associations with incident heart failure (HF), coronary heart disease (CHD), and stroke were measured.
Methods: The UK Biobank is a prospective cohort study comprising over 500,000 participants recruited in the United Kingdom between 2006 and 2010, aged 37 to 73 years.
Investigating the impact of multidimensional sleep traits on cardiovascular diseases and the mediating role of depression.
Open Heart
March 2025
Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Background: Observational studies have reported that sleep is associated with the risk of major depressive disorder (MDD) and cardiovascular diseases (CVDs). However, the causal relationships among various sleep traits remain contentious, and whether MDD mediates the impact of specific sleep traits on CVDs is unclear.
Methods: We performed two-sample Mendelian randomisation analyses to explore whether insomnia, sleep time, daytime napping, daytime sleepiness, chronotype, snoring or obstructive sleep apnoea were causally associated with the risk of five CVDs, including coronary artery disease (CAD), myocardial infarction (MI), heart failure (HF), atrial fibrillation and stroke.
Perioperative Management of Direct Oral Anticoagulants in Patients having a High-Bleed-Risk Surgery or Neuraxial Procedure: The PAUSE-2 Pilot Randomized Trial.
J Thromb Haemost
March 2025
Department of Medicine, Anticoagulation and Clinical Thrombosis Service, Northwell Health at Lenox Hill Hospital, New York, NY, the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, and the Institute of Health Systems Science at The Feinstein Institutes for Medical Research, Manhasset, NY, USA.
Background: There is uncertainty about the perioperative management of patients who are receiving a direct oral anticoagulant (DOAC) and require an elective high-bleed-risk surgery, including those who are undergoing a neuraxial or deep peripheral nerve block procedure.
Methods: The Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE)-2 pilot trial was a proof-of-concept, open-label, randomized controlled trial that assessed the feasibility of comparing perioperative DOAC management using an American Society of Regional Anesthesia (ASRA)-based or PAUSE-based approach in patients with atrial fibrillation who needed an elective high-bleed-risk surgery/procedure and/or any neuraxial anesthesia/procedure.
Results: There were 159 patients enrolled (86 on apixaban, 12 on dabigatran, and 61 on rivaroxaban), of whom 141 had pre-operative DOAC level testing done.
Silencing RGS7 attenuates atrial fibrillation progression by activating the cGMP-PKG signaling pathway.
Biochim Biophys Acta Mol Basis Dis
March 2025
Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu City, PR China. Electronic address:
Background: Atrial fibrillation (AF) is a common diagnosed heart disease that needs novel managements. This study aimed to seek potential biomarkers and underlying regulatory pathways associated with AF.
Methods: Differential expressed genes (DEGs) were identified from the Gene Expression Omnibus database, followed by a protein-protein interaction (PPI) network to discover hub genes.
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