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Radiological evolution of pituitary hyperplasia in primary hypothyroidism and its differentiation from nonfunctioning pituitary adenoma coexisting with primary hypothyroidism.
Endocrine
October 2024
Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, India.
Article Synopsis
- The study aims to distinguish between isolated pituitary hyperplasia (IPH) and primary hypothyroidism with a nonfunctioning pituitary adenoma (PHCNFPA) in patients with high thyroid stimulating hormone (TSH) levels and sellar masses to prevent unnecessary surgeries.
- Using a retrospective analysis of patients with TSH >50 µIU/ml from 2020-2022, researchers examined MRI results, symptoms, and other clinical data to categorize patients into IPH or PHCNFPA.
- Results indicated a significant age difference between the two groups, with IPH patients presenting at a younger age, while PHCNFPA patients showed more severe symptoms and larger pituitary lesions; unique imaging features helped in differentiating
Seasonality of Reproduction in a Subtropical Free-Living Finch Amandava amandava: Plasticity of Adenohypophyseal Gonadotropes, Lactotropes, and Thyrotropes.
Neuroendocrinology
June 2024
Department of Zoology, University of Allahabad, Prayagraj, India.
Introduction: This study sought to decipher the mechanism of transitions between life-history stages in a seasonally reproducing subtropical finch, Amandava amandava delineating the plasticity of the gonadotropes (LH cells), lactotropes (PRL cells), and thyrotropes (TSH cells) in the pituitary gland including the pars tuberalis, with regard to the in situ expression, morphological characteristics, and alteration in the plasma levels of hormones.
Methods: Immunohistochemistry of LH, PRL, TSH cells, morphometry and densitometry of expressed hormones (Image J software analysis), and ELISA for plasma hormonal levels were performed.
Results: LH, PRL, and TSH cells showed remarkable plasticity during the annual seasonal reproductive cycle.
Thyroid-stimulating hormone-thyroid hormone signaling contributes to circadian regulation through repressing clock2/npas2 in zebrafish.
J Genet Genomics
January 2024
Center for Circadian Clocks, Soochow University, Suzhou, Jiangsu 215123, China; School of Biology and Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address:
Thyroid-stimulating hormone (TSH) is important for the thyroid gland, development, growth, and metabolism. Defects in TSH production or the thyrotrope cells within the pituitary gland cause congenital hypothyroidism (CH), resulting in growth retardation and neurocognitive impairment. While human TSH is known to display rhythmicity, the molecular mechanisms underlying the circadian regulation of TSH and the effects of TSH-thyroid hormone (TH) signaling on the circadian clock remain elusive.
View Article and Find Full Text PDF3D Atlas of the Pituitary Gland of the Model Fish Medaka ().
Front Endocrinol (Lausanne)
February 2022
Physiology Unit, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås, Norway.
In vertebrates, the anterior pituitary plays a crucial role in regulating several essential physiological processes the secretion of at least seven peptide hormones by different endocrine cell types. Comparative and comprehensive knowledge of the spatial distribution of those endocrine cell types is required to better understand their physiological functions. Using medaka as a model and several combinations of multi-color fluorescence hybridization, we present the first 3D atlas revealing the gland-wide distribution of seven endocrine cell populations: lactotropes, thyrotropes, Lh and Fsh gonadotropes, somatotropes, and -expressing cells (corticotropes and melanotropes) in the anterior pituitary of a teleost fish.
View Article and Find Full Text PDFSomatostatin receptor ligands induce TSH deficiency in thyrotropin-secreting pituitary adenoma.
Eur J Endocrinol
January 2021
Centre de Référence des Maladies Rares de la Thyroïde et des Récepteurs Hormonaux TRH Centre de Référence des Maladies Rares de l'Hypophyse HYPO Service d'Endocrinologie, Diabétologie et Nutrition, CHU d'Angers, Institut MITOVASC, Université d'Angers, Angers, France.
Objective: Somatostatin receptor ligands (SRL) are useful to control central hyperthyroidism in patients with thyrotropin-secreting pituitary adenoma (TSH pituitary adenoma). The aim of this study was to describe the frequency of thyrotropin deficiency (TSH deficiency) in patients with TSH pituitary adenoma treated by SRL.
Design: Retrospective study.
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