An international HIV pharmacology specialty laboratory (PSL) was established at the University of Zimbabwe to increase bioanalytical and investigator capacities. Quantitation of plasma nevirapine in samples from the AIDS Clinical Trials Group protocol 5279 was compared between the University of Nebraska Medical Center PSL and the University of Zimbabwe PSL. Both PSLs employed internally developed methods utilising reverse-phase high-performance liquid chromatography with ultraviolet detection. Eighty-seven percent of the cross-validation results exhibited ± 20% difference.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335789 | PMC |
| http://dx.doi.org/10.4102/ajlm.v10i1.1264 | DOI Listing |
Publication Analysis
Top Keywords
high-performance liquid
8
liquid chromatography
8
university zimbabwe
8
cross-validation high-performance
4
chromatography nevirapine
4
nevirapine plasma
4
plasma assay
4
assay resource-limited
4
resource-limited setting
4
setting zimbabwe
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!