Background: Breast cancer is the most commonly diagnosed cancer amongst women worldwide. Whilst current evidence indicates the therapeutic benefits from the use of chemotherapy, self-perceived cognitive difficulties emerged as a frequent occurrence during and after chemotherapy treatment in breast cancer patients.
Aim: The current study sought to investigate self-perceived cognitive impairment in a group of breast cancer patients in semi-rural South Africa.
Setting: The patients were recruited from an outpatient oncology clinic at a semi-rural, tertiary academic hospital in Gauteng, South Africa.
Methods: In a randomised, quantitative, time-based series study, 30 female patients aged 21-60 years (mean age = 50 years) diagnosed with stages II and III breast cancer on CMF (cyclophosphamide, methotrexate, fluorouracil) ( = 10) and FAC (fluorouracil, adriamycin, cyclophosphamide) ( = 20) chemotherapy regimens, completed the self-reported Functional Assessment of Cancer Therapy-Cognition (Fact-Cog) test as a measure of subjective cognitive functioning at three points during the course of treatment (T, T, T).
Results: The results of the paired sample -tests showed the scores on the Fact-Cog test confirmed significant cognitive decline for both treatment groups from baseline (T) to completion (T) of chemotherapy; CMF group, (9) = 2.91, = 0.017 and the FAC group (19) = 4.66, < 0.001.
Conclusion: This study confirms that self-reported subjective cognitive impairment is common in breast cancer patients who received chemotherapy in a sample of South African patients. The results have implications for the overall care of cancer patients.
Contribution: The context-based knowledge engendered by the current study is expected to augment the continuum of care for breast cancer patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335783 | PMC |
| http://dx.doi.org/10.4102/hsag.v26i0.1605 | DOI Listing |
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