Background: Clear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate.
Objective And Methods: Patients with MS (=12) and neuromyelitis optica spectrum disorder (NMOSD; =12) were enrolled along with 15 healthy controls. Changes in lymphocyte subset proportions during stimulation of their peripheral blood mononuclear cells (PBMCs) with the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)D), and correlations with serum concentrations of the vitamin D precursor 25-hydroxyvitamin D (serum 25(OH)D) were explored. The impact of 1,25(OH)D stimulation on the expression of vitamin-D-responsive genes in immune cells was also investigated.
Results: In both MS and NMOSD, stimulation of PBMCs with 1,25(OH)D followed by steroid suppressed the proliferation of total lymphocytes and T cells. The ratio of CD19CD27 memory B cells (Bmem) to all B cells after stimulation with 1,25(OH)D was negatively correlated with serum 25(OH)D in MS (Spearman's =-0.594, =0.042), but positively correlated in NMOSD (Pearson's = 0.739, =0.006). However, there was no relationship between the ratio of Bmem to CD19CD24CD38 regulatory B cells and serum 25(OH)D in either MS or NMOSD. In addition, the level of 1,25(OH)D-induced mRNA expression in PBMCs was significantly and negatively correlated with serum 25(OH)D (for ΔC, =0.744, =0.014) in MS.
Conclusion: These findings suggest a beneficial impact of stimulation of PBMCs with vitamin D followed by steroid on the T-cell population. The association between patient serum 25(OH)D and the proportion of Bmem under immune-cell stimulation differed between MS and NMOSD. Further investigations are warranted with larger patient populations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358328 | PMC |
| http://dx.doi.org/10.3389/fimmu.2021.677041 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vitamin D and COVID-19: comparative analysis with other respiratory infections and impact of comorbidities.
Germs
September 2024
Pharm, PhD, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, No. 6 Traian Vuia street, Bucharest, 020956, Romania.
Introduction: The COVID-19 pandemic has promoted an intensive investigation into the pathophysiological mechanisms of SARS-CoV-2 infection, risk factors, and its impact on disease severity. Vitamin D has generated significant attention for its potential role in viral prevention and immune defense due to its pleiotropic functions, including immunomodulation and antimicrobial effects. This study aimed to assess serum 25(OH)D3 levels in patients with COVID-19 compared to those with other viral respiratory infections and to evaluate associations of vitamin D levels with symptomatology, clinical characteristics, presence of comorbidities and laboratory investigation.
View Article and Find Full Text PDFLow 25-Hydroxyvitamin D Post-Kidney Transplant Is Associated with Increased Risk of BK Polyomavirus-Associated Nephropathy.
Microorganisms
December 2024
Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
BK viremia (BKPyV-DNAemia) and nephropathy (BKPyVAN) are significant causes of morbidity and mortality in kidney transplant recipients (KTRs). Vitamin D supports immune function, yet low 25-hydroxyvitamin D [25(OH)D] is common among KTRs. The association between serum 25(OH)D, measured 61 days to 2 years post-transplant, and subsequent incident BKPyV-DNAemia and BKPyVAN was examined in KTRs without previous BKPyV-DNAemia or BKPyVAN, respectively.
View Article and Find Full Text PDFAssociation between vitamin D status at 3 years and eosinophilic asthma in 6-year-old children with a history of severe bronchiolitis.
Thorax
January 2025
Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
The association between early childhood serum 25-hydroxyvitamin D (25(OH)D) and eosinophilic asthma remains unclear. We investigated this association using multicentre prospective data from 584 children with a history of bronchiolitis requiring hospitalisation (high-risk population). Low serum 25(OH)D levels (<20 ng/mL) were associated with increased odds of developing eosinophilic asthma (adjusted OR 2.
View Article and Find Full Text PDFEffects of vitamin D supplementation on oxidative stress and antioxidant enzyme after strenuous endurance exercise in healthy young men: a double-blind, placebo-controlled trial.
Biol Sport
January 2025
Center for General Education, Taipei Medical University, Taipei, Taiwan.
Vitamin D exhibits strong antioxidant properties. However, its effect on oxidative stress after strenuous endurance exercise remains unclear. Therefore, we investigated the effects of vitamin D supplementation on strenuous endurance-exercise-induced oxidative stress.
View Article and Find Full Text PDFVitamin D status and its determinants in German elite athletes.
Eur J Appl Physiol
January 2025
Department of Exercise Physiology and Sports Therapy, Institute of Sports Science, Justus Liebig University Giessen, Kugelberg 62, 35394, Giessen, Germany.
Purpose: This study investigated elite German athletes to (1) assess their serum 25(OH)D levels and the prevalence of insufficiency, (2) identify key factors influencing serum 25(OH)D levels, and (3) analyze the association between serum 25(OH)D levels and handgrip strength.
Methods: In this cross-sectional study, a total of 474 athletes (231 female), aged 13-39 years (mean 19.3 years), from ten Olympic disciplines were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!