AI Article Synopsis
- - A newly discovered symbiont has a strong potential to block malaria transmission in a key mosquito species found in eastern Africa, making it important for developing malaria control strategies.
- - The study shows that this symbiont does not spread between mosquito larvae but is effectively transmitted between adult mosquitoes through sexual interactions, especially between males and females.
- - Female mosquitoes that acquire the symbiont from males can pass it on to their offspring, and while no other hosts were found, the symbiont was identified in another mosquito species that spreads malaria, highlighting its potential for targeted release in control efforts.
Article Abstract
The recently discovered symbiont, , has a strong malaria transmission-blocking phenotype in , the predominant species complex member in many active transmission areas in eastern Africa. The ability of to block transmission together with vertical transmission and avirulence makes it a candidate for the development of a symbiont-based malaria transmission blocking strategy. We investigate the characteristics and efficiencies of transmission between mosquitoes. We show that is not transmitted between larvae but is effectively transmitted horizontally between adult mosquitoes. Notably, was only found to be transmitted between male and female , suggesting sexual horizontal transmission. In addition, cells were observed infecting the ejaculatory duct. Female that acquire horizontally are able to transmit the symbiont vertically to their offspring. We also investigate the possibility that can infect alternate hosts that live in the same habitats as their hosts, but find no other non-anopheline hosts. Notably, infections were found in another primary malaria African vector, . The finding that can be transmitted horizontally is relevant for the development of dissemination strategies to control malaria that are based on the targeted release of infected mosquitoes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355901 | PMC |
| http://dx.doi.org/10.3389/fmicb.2021.647183 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Potential links between human bloodstream infection by Salmonella enterica serovar Typhimurium and international transmission to Colombia.
PLoS Negl Trop Dis
January 2025
Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Salmonella enterica serovar Typhimurium is a prevalent food-borne pathogen that is usually associated with gastroenteritis infection. S. Typhimurium is also a major cause of bloodstream infections in sub-Saharan Africa, and is responsible for invasive non-typhoidal Salmonella (iNTS) disease.
View Article and Find Full Text PDFEmergence of a novel group B streptococcus CC61 clade associated with human infections in southern China.
J Infect
January 2025
National Key Laboratory of Agricultural Microbiology, College of Fisheries, Huazhong Agricultural University, Wuhan, PR China; Hubei Hongshan Laboratory, Wuhan, PR China; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Wuhan, PR China. Electronic address:
Objectives: Emerging human pathogens of animal origin have become an increasing public health concern in recent years. The aim of this study was to investigate the transmission of group B streptococcus (GBS) clonal complex (CC) 61 strains in the southern Chinese population and analyze their genetic characteristics.
Methods: Whole-genome sequencing was performed on 693 clinical isolates of GBS collected from southern China between 2016 and 2021, and the prevalence of human CC61 isolates was investigated by genomic epidemiology.
Enhancing farmer awareness: Vertical transmission of Neospora caninum in aborting cattle and the value of diagnostics tools.
Vet Parasitol
January 2025
Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, Bern 3012, Switzerland. Electronic address:
The protozoan parasite Neospora caninum is an important cause of abortion in cattle. Infection occurs horizontally by ingestion of oocysts shed by canids or vertically, from an infected dam to the foetus, and may result in abortion, stillbirth, or the birth of subclinically infected offspring. We estimated the occurrence of N.
View Article and Find Full Text PDFPf bacteriophages, lysogenic viruses that infect are implicated in the pathogenesis of chronic infections; phage-infected (Pf+) strains are known to predominate in people with cystic fibrosis (pwCF) who are older and have more severe disease. However, the transmission patterns of Pf underlying the progressive dominance of Pf+ strains are unclear. In particular, it is unknown whether phage transmission commonly occurs horizontally between bacteria within the airway via viral particles or if Pf+ bacteria are mostly acquired via new infections.
View Article and Find Full Text PDFMolecular Epidemiology of Type F Among Diarrheal Patients and Virulence-Resistance Dynamics - 11 Provinces, China, 2024.
China CDC Wkly
January 2025
Department of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, China.
Introduction: Type F () represents a significant pathogen in human gastrointestinal diseases, primarily through its gene encoding enterotoxin (CPE). This investigation examined the prevalence, antimicrobial resistance patterns, and genetic characteristics of Type F within the Chinese population.
Methods: The study analyzed 2,068 stool samples collected from 11 provincial hospitals in 2024.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!