AI Article Synopsis
- A significant measles outbreak in New York City involved cases among vaccinated individuals, revealing insights into vaccine failures and their effects on transmission.
- Researchers measured measles IgG avidity in 62 people, finding that most had high avidity (53), indicating prior immunity, while 9 had low avidity, suggesting potential recent vaccination or lack of immunity.
- The study shows that even with prior vaccination, people can still transmit measles during outbreaks, highlighting the importance of vigilance for measles cases regardless of vaccination history.
Article Abstract
A large measles outbreak in New York City, which included cases among vaccinated persons and adults presumed to be immune, provided the opportunity to better understand vaccine failure and the potential impact on measles transmission. Immunoglobulin G (IgG) avidity can distinguish primary (low avidity IgG, indicating no evidence of prior immunity) versus secondary vaccine failure (high avidity IgG, indicating prior immune response and waning antibody). Measles IgG avidity was measured on samples from 62 persons: avidity was high in 53 (16 vaccinated and 37 with unknown vaccination history) and low in 9 (1 recently vaccinated and 8 with unknown vaccination history). Secondary transmission from 2 persons with high-avidity IgG results occurred. These findings illustrate that in settings of sustained measles elimination, measles infection and transmission can occur in persons with secondary vaccine failure, underscoring the need to maintain a high index of suspicion for measles during an outbreak despite prior or presumed prior vaccination.
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| http://dx.doi.org/10.1016/j.vaccine.2021.07.078 | DOI Listing |
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