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Tissue specificity of DNA repair: the CRISPR compass. | LitMetric

Tissue specificity of DNA repair: the CRISPR compass.

Trends Genet

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

Published: November 2021

AI Article Synopsis

Article Abstract

CRISPR-Cas9-mediated genome editing holds great promise for the correction of pathogenic variants in humans. However, its therapeutic implementation is hampered due to unwanted editing outcomes. A better understanding of cell type- and tissue-specific DNA repair processes will ultimately enable precise control of editing outcomes for safer and effective therapies.

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Source
http://dx.doi.org/10.1016/j.tig.2021.07.010DOI Listing

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