AI Article Synopsis
- Recent advancements in hematological neoplasm classifications have favored genome-based methods over traditional histologic ones.
- Studies reveal that genetic differences exist among racial groups, potentially affecting the effectiveness of these classifications across diverse populations.
- Our research validated a genomic classification for myelodysplastic syndromes (MDS) in Chinese patients, highlighting significant racial differences that suggest the need for tailored genomic approaches based on specific ethnic genetic characteristics.*
Article Abstract
In recent years, genome-based classifications for hematological neoplasms have been proposed successively and proved to be more accurate than histologic classifications. However, some previous studies have reported the racial differences of genetic landscape in persons with hematological neoplasms including myelodysplastic syndromes (MDS), which may cause a genomic classification based on a particular ethnic group does not operate in other races. To determine whether race plays an important role in the genomic-based classification, we validated a newly proposed genomic classification of MDS (J Clin Oncol.2021; JCO2001659), which was based on a large European database, in Chinese patients from our center. Our results showed significant differences between Chinese and European patients including proportion of each group to overall cohort when applying this novel genomic classification. Our data indicate that a genomic classification of hematological neoplasms probably should be revised according to specific genetic features in different races.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hon.2909 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!