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Short-course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy.
Allergy
November 2024
Department of Otorhinolaryngology, Technische Universität Dresden, Dresden, Germany.
Background: Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of the mannan-conjugated birch pollen polymerized allergoid T502 in birch pollen-induced allergic rhinoconjunctivitis.
Methods: In this prospective, randomized, double-blind placebo-controlled phase III trial, 298 birch pollen-allergic adult patients were treated across 28 trial sites in Germany.
Allergenic Potential of Common Hops ( L.) in the Context of Cross-Reactions with Pollen Allergens.
Nutrients
October 2024
Specialized Non-Public Health Care Facility Alergologia Plus, Allergy Diagnostics and Therapy Center, 60-693 Poznan, Poland.
Background: Common hops ( L.) play a key role in brewing, providing the bitterness, flavor, and aroma of beer, and are widely used in supplements for their antibacterial, anti-inflammatory, and antioxidant properties. However, despite their broad applications, the allergenic potential of common hops remains underexplored, particularly when compared to the closely related .
View Article and Find Full Text PDFDevelopment of a graphene field effect transistor-based immersible biosensor for immunodetection of the birch pollen allergen Bet v 1 in air samples.
Heliyon
October 2024
Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, 5020, Austria.
Pollen traps, the current gold standard to determine pollen load and thereby the allergy season, are not sufficient to determine the allergenic risk. Therefore, the establishment of highly sensitive assays for allergen measurement is of highest interest. Herein, a graphene field-effect transistor (GFET) was constructed on an interdigitated electrodes chip to develop an immersible biosensor, which was used to detect the major birch pollen allergen Bet v 1.
View Article and Find Full Text PDFCharacterization of the Immune-Modulating Properties of Different β-Glucans on Myeloid Dendritic Cells.
Int J Mol Sci
September 2024
Section Molecular Allergology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
In allergen-specific immunotherapy, adjuvants are explored for modulating allergen-specific Th2 immune responses to re-establish clinical tolerance. One promising class of adjuvants are β-glucans, which are naturally derived sugar structures and components of dietary fibers that activate C-type lectin (CLR)-, "Toll"-like receptors (TLRs), and complement receptors (CRs). We characterized the immune-modulating properties of six commercially available β-glucans, using immunological (receptor activation, cytokine secretion, and T cell modulating potential) as well as metabolic parameters (metabolic state) in mouse bone marrow-derived myeloid dendritic cells (mDCs).
View Article and Find Full Text PDFSilencing of RDR1 and RDR6 genes by a single RNAi enhances lettuce's capacity to express recombinant proteins in transient assays.
Plant Cell Rep
September 2024
Graduate School of Life and Earth Sciences, University of Tsukuba, Tsukuba, 305-8572, Japan.
Enhanced recombinant protein expression was achieved in Salinas lettuce and commercial lettuce by designing a unique RNAi that knockdown the gene-silencing mechanism in transient assays. Improved yields of recombinant proteins (RP) are necessary for protein-production efficiency and ease of purification. Achieving high yield in non-tobacco plants will enable diverse plants to be used as hosts in transient protein-expression systems.
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