AI Article Synopsis
- Last year saw major advancements in asthma management despite pandemic challenges, highlighting important discoveries in asthma mechanisms involving resident cells, epigenetics, and the innate immune system.
- Precision immunology techniques, enhanced by artificial intelligence, played a key role in these advancements and aided in revising existing asthma treatment guidelines.
- The review aims to summarize recent studies and clinical trials to give clinicians and researchers a clear update on the latest developments in asthma research from a practical viewpoint.
Article Abstract
Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real-world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.
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| http://dx.doi.org/10.1111/all.15054 | DOI Listing |
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