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| http://dx.doi.org/10.1093/jac/dkab285 | DOI Listing |
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Increasing Trends of Association of 16S rRNA Methylases and Carbapenemases in Clinical Isolates from Switzerland, 2017-2020.
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Medical and Molecular Microbiology Unit, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
Aminoglycosides (AGs) in combination with β-lactams play an important role in antimicrobial therapy in severe infections. Pan-resistance to clinically relevant AGs increasingly arises from the production of 16S rRNA methylases (RMTases) that are mostly encoded by plasmids in Gram-negative bacteria. The recent emergence and spread of isolates encoding RMTases is worrisome, considering that they often co-produce extended-spectrum β-lactamases (ESBLs) or carbapenemases.
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Technical University of Denmark, National Food Institute, European Union Reference Laboratory for Antimicrobial Resistance (EURL-AMR), WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and Genomics, FAO Reference Laboratory for Antimicrobial Resistance (FAO RL), Kgs Lyngby, Denmark.
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