Emerging evidence indicates that circular RNA (circRNA) and N-methyladenosine (mA) play critical roles in cervical cancer. However, the synergistic effect of circRNA and mA on cervical cancer progression is unclear. In the present study, our sequencing data revealed that a novel mA-modified circRNA (circARHGAP12, hsa_circ_0000231) upregulated in the cervical cancer tissue and cells. Interestingly, the mA modification of circARHGAP12 could amplify its enrichment. Functional experiments illustrated that circARHGAP12 promoted the tumor progression of cervical cancer in vivo and vitro. Furthermore, MeRIP-Seq illustrated that there was a remarkable mA site in FOXM1 mRNA. CircARHGAP12 interacted with mA reader IGF2BP2 to combine with FOXM1 mRNA, thereby accelerating the stability of FOXM1 mRNA. In conclusion, we found that circARHGAP12 exerted the oncogenic role in cervical cancer progression through mA-dependent IGF2BP2/FOXM1 pathway. These findings may provide new concepts for cervical cancer biology and pathological physiology.
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| http://dx.doi.org/10.1038/s41420-021-00595-w | DOI Listing |
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