AI Article Synopsis
- There is a worry that a type of tumor in the salivary gland, called pleomorphic adenoma, can turn cancerous, which makes doctors want to treat it hard if it comes back.
- Scientists studied a specific case and found that changes in the DNA helped them see how the tumor changed from benign to cancerous.
- They identified particular DNA changes in the tumor that stayed the same even when it came back as cancer, showing that studying these changes can help doctors recognize when a tumor becomes malignant.
Article Abstract
Supposed risk of malignant transformation of salivary gland pleomorphic adenoma (SGPA) is an important reason for aggressive retreatment in recurrent pleomorphic adenoma (RPA). However, although the diagnostic category 'carcinoma ex-pleomorphic adenoma' suggests that malignant transformation of a pleomorphic adenoma is a regular event, this has to date not been shown to occur in sequential lesions of one patient. Here, we show the molecular events in transformation to malignancy of a pleomorphic adenoma of the parotid gland. Detailed molecular analysis revealed an LIFR/PLAG1 translocation characteristic for pleomorphic adenoma and, next to this, a PIK3R1 frameshift mutation and several allelic imbalances. In subsequent malignant recurrences, the same LIFR/PLAG1 translocation, PIK3R1 frameshift mutation, and allelic imbalances were present in addition to TP53 mutations. Thus, this case not only shows malignant transformation of SGPA, but also demonstrates that molecular analysis can be of help in recognising malignancy in the rare instance of RPA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363925 | PMC |
| http://dx.doi.org/10.1002/cjp2.216 | DOI Listing |
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