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| http://dx.doi.org/10.1038/s41418-021-00846-4 | DOI Listing |
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Impact of chronic ethanol consumption and SARS-COV-2 on the liver and intestine: A pilot dose-response study in mice.
Alcohol Clin Exp Res (Hoboken)
January 2025
Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA.
Background: During the coronavirus disease 2019 (COVID-19) pandemic, there was a marked increase in alcohol consumption. COVID-19 superimposed on underlying liver disease notably worsens the outcome of many forms of liver injury. The goal of a current pilot study was to test the dual exposure of alcohol and COVID-19 infection in an experimental animal model of alcohol-associated liver disease (ALD).
View Article and Find Full Text PDFExploring B-cell epitope conservation and antigenicity shift in current COVID-19 variants: Analyzing spike-antibody interactions for therapeutic uses.
Biochem Biophys Res Commun
December 2024
Amity Institute of Biotechnology, Amity University, Kolkata, India. Electronic address:
SARS-CoV-2, responsible for the global COVID-19 pandemic, has undergone significant genetic changes, leading to various variants impacting transmissibility, severity, and vaccine efficacy. The methodology involved evaluating SARS-CoV-2 variants designated by WHO as Variants of Interest (VOIs) and Variants Under Monitoring (VUMs). Several noteworthy mutations including G446S, K417N, T478K, E484A, N501Y, and Y505H exhibit a strong pattern of convergent evolution across all these variants, particularly at antigenic sites within the spike protein.
View Article and Find Full Text PDFCharacterization of the viral genome of Omicron variants of SARS-CoV-2 circulating in Tripura, a remote frontier state in Northeastern India.
Mol Biol Rep
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Medical Research Scientist, Viral Research & Diagnostic Laboratory, Agartala Government Medical College & GBP Hospital, Agartala, India.
Introduction: From 2020, with advent of COVID-19 pandemic, Tripura has experienced SARS-CoV-2 viral evolution in accordance with other parts of India. Since January 2022, the Omicron variant of SARS-CoV-2 virus became the predominant lineage circulating in India and neighboring countries. This study characterizes the viral genome of the omicron variant circulating in the state since its inception to June, 2023.
View Article and Find Full Text PDFSewage surveillance of SARS-CoV-2 in Tokyo (May 2020-June 2022): method using high-throughput, fully-automated platform.
Virusdisease
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Department of Microbiology, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-Cho, Shinjuku-Ku, Tokyo, 169-0073 Japan.
Article Synopsis
- SARS-CoV-2, the virus responsible for COVID-19, can be found in patients' saliva, sputum, and feces, leading to the detection of its RNA in sewage as a way to monitor the spread of the virus.
- A study conducted in Tokyo from May 2020 to June 2022 utilized an automated genetic testing method to monitor two wastewater treatment plants for SARS-CoV-2 RNA.
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Molecular Characterization and Genomic Surveillance of SARS-CoV-2 Lineages in Central India.
Viruses
October 2024
ICMR-National Institute of Research in Tribal Health, Jabalpur 482003, Madhya Pradesh, India.
Since the first reported case of COVID-19 in December 2019, several SARS-CoV-2 variants have evolved, and some of them have shown higher transmissibility, becoming the prevalent strains. Genomic epidemiological investigations into strains from different time points, including the early stages of the pandemic, are very crucial for understanding the evolution and transmission patterns. Using whole-genome sequences, our study describes the early landscape of SARS-CoV-2 variants in central India retrospectively (including the first known occurrence of SARS-CoV-2 in Madhya Pradesh).
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