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Neural excitability increases with axonal resistance between soma and axon initial segment. | LitMetric

Neural excitability increases with axonal resistance between soma and axon initial segment.

Proc Natl Acad Sci U S A

UMR 1072, INSERM, Unité de Neurobiologie des canaux Ioniques et de la Synapse, Aix-Marseille Université, 13015 Marseille, France;

Published: August 2021

AI Article Synopsis

Article Abstract

The position of the axon initial segment (AIS) is thought to play a critical role in neuronal excitability. Previous experimental studies have found that a distal shift in AIS position correlates with a reduction in excitability. Yet theoretical work has suggested the opposite, because of increased electrical isolation. A distal shift in AIS position corresponds to an elevation of axial resistance We therefore examined how changes in at the axon hillock impact the voltage threshold (V) of the somatic action potential in L5 pyramidal neurons. Increasing by mechanically pinching the axon between the soma and the AIS was found to lower V by ∼6 mV. Conversely, decreasing by substituting internal ions with higher mobility elevated V All -dependent changes in V could be reproduced in a Hodgkin-Huxley compartmental model. We conclude that in L5 pyramidal neurons, excitability increases with axial resistance and therefore with a distal shift of the AIS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379991PMC
http://dx.doi.org/10.1073/pnas.2102217118DOI Listing

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