AI Article Synopsis
- Rare bleeding disorders (RBD) like deficiencies in factors II, V, VII, and X account for about 5% of inherited bleeding disorders globally and are crucial in blood clotting.
- Incomplete evaluations and misinterpretation of lab tests can lead to delayed diagnoses, impacting patient health outcomes.
- The best treatment for RBD involves using specific single-factor concentrates for managing acute bleeding, surgical needs, and preventative care.
Article Abstract
Although rare clotting factor deficiencies primarily referred to as rare bleeding disorders (RBD), including factors II, V, VII, and X, make up ∼5% of all inherited bleeding disorders worldwide, each of these clotting factors play a critical role in the coagulation cascade. Incomplete bleeding evaluation or misinterpretation of laboratory studies can result in delayed diagnoses that ultimately affect patient outcomes. Bleeding manifestations can range from mild to severe, but the most common are mucocutaneous bleeding. The ideal treatment in RBD is dedicated single-factor concentrates that can be used for acute bleeding events, surgical management, and prophylaxis.
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| http://dx.doi.org/10.1016/j.hoc.2021.07.010 | DOI Listing |
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