AI Article Synopsis
- The treatment of infrarenal aortic aneurysms has evolved, with endovascular aneurysm repair (EVAR) now being the preferred method for suitable patients, though no serum biomarker for follow-up currently exists.
- A study on 30 patients who underwent EVAR showed that the serum levels of miRNA-1281 significantly decreased after the procedure, indicating a potential relationship between this marker and the success of the treatment.
- The research suggests that miRNA-1281 might serve as a useful biomarker for monitoring patients post-EVAR, although further investigation is needed to confirm its clinical utility.
Article Abstract
Introduction: The treatment of infrarenal aortic aneurysms has changed in the last three decades. Endovascular aneurysm repair (EVAR) has become the primary treatment option in anatomically suitable patients with infrarenal aortic aneurysms. However, there is no serum biomarker to be used in EVAR follow-up.
Methods: This is a prospective single-centre study of 30 consecutive patients with abdominal aortic aneurysm (AAA) who underwent EVAR. Serum dosages of micro ribonucleic acid 1281 (miRNA-1281), creatinine, total cholesterol, triglycerides, and C-reactive protein (CRP) were evaluated and angiotomographic evaluations were performed preoperatively and six months after the intervention.
Results: There was a hyperexpression of miRNA-1281 in patients with AAA and a significant reduction of it after EVAR, from 1.66-fold before EVAR to 0.27 after the procedure (P<0.0001). MiRNA-1281 expression was not influenced by renal function (creatinine: 1.14±0.29, P=0.68), total cholesterol (179.9±59.9, P=0.22), or CRP (1.17±3.5; P=0.48). There is correlation between AAA size and CRP serum levels, however there was no statically significant reduction of CRP after EVAR.
Discussion: MiRNA-1281 expression may be influenced by cholesterol, triglycerides levels, and renal function. We found no difference in these markers before and six months after EVAR. However, miRNA-1281 presents a significant reduction in patients with no follow-up complications. We hypothesize that miRNA-1281 expression may be related to aortic wall stress or flow changes.
Conclusion: MiRNA-1281 may contribute as a possible marker of EVAR follow-up.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357382 | PMC |
| http://dx.doi.org/10.21470/1678-9741-2020-0268 | DOI Listing |
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