The homeobox gene TGIF1 is required for chicken ovarian cortical development and generation of the juxtacortical medulla.

Development

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia.

Published: August 2021

During early embryogenesis in amniotic vertebrates, the gonads differentiate into either ovaries or testes. The first cell lineage to differentiate gives rise to the supporting cells: Sertoli cells in males and pre-granulosa cells in females. These key cell types direct the differentiation of the other cell types in the gonad, including steroidogenic cells. The gonadal surface epithelium and the interstitial cell populations are less well studied, and little is known about their sexual differentiation programs. Here, we show the requirement of the homeobox transcription factor gene TGIF1 for ovarian development in the chicken embryo. TGIF1 is expressed in the two principal ovarian somatic cell populations: the cortex and the pre-granulosa cells of the medulla. TGIF1 expression is associated with an ovarian phenotype in estrogen-mediated sex reversal experiments. Targeted misexpression and gene knockdown indicate that TGIF1 is required, but not sufficient, for proper ovarian cortex formation. In addition, TGIF1 is identified as the first known regulator of juxtacortical medulla development. These findings provide new insights into chicken ovarian differentiation and development, specifically cortical and juxtacortical medulla formation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406534PMC
http://dx.doi.org/10.1242/dev.199646DOI Listing

Publication Analysis

Top Keywords

juxtacortical medulla
12
gene tgif1
8
tgif1 required
8
chicken ovarian
8
pre-granulosa cells
8
cell types
8
cell populations
8
tgif1
6
ovarian
6
cell
5

Similar Publications

Case report: Central alveolar hypoventilation in a survivor of cardiopulmonary arrest.

Front Neurol

August 2023

Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.

Introduction: Ondine's curse is a rare respiratory disorder that is characterized by central alveolar hypoventilation (CAH) during sleep. It is most commonly congenital. However, it can also be acquired very rarely.

View Article and Find Full Text PDF

Unlabelled: A 40-year-old woman known hypertensive presented with progressive ascending paralysis. MRI T2W and FLAIR screening of the brain demonstrated swelling with altered signal in the visual cervical cord, medulla, and another juxtacortical lesion in the right temporal lobe with possibility of a demyelinating etiology. CSF testing did not identify a direct cerebral infection.

View Article and Find Full Text PDF

Background: Exclusive emesis has been observed in few patients of MOG-associated disorder (MOGAD).

Objectives: To study the occurrence of emesis in patients of Demyelinating disorders and determine their clinical and radiological features.

Methods And Results: Medical records of 551 patients of CNS demyelinating disorders were reviewed.

View Article and Find Full Text PDF

The homeobox gene TGIF1 is required for chicken ovarian cortical development and generation of the juxtacortical medulla.

Development

August 2021

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia.

During early embryogenesis in amniotic vertebrates, the gonads differentiate into either ovaries or testes. The first cell lineage to differentiate gives rise to the supporting cells: Sertoli cells in males and pre-granulosa cells in females. These key cell types direct the differentiation of the other cell types in the gonad, including steroidogenic cells.

View Article and Find Full Text PDF

Brain magnetic resonance imaging abnormalities in neuromyelitis optica.

Acta Neurol Scand

October 2008

Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Objective: Brain abnormalities in neuromyelitis optica (NMO) attracted much attention. Our study was to identify the brain magnetic resonance imaging (MRI) abnormalities in Chinese NMO patients.

Methods: Patients who fulfilled the latest diagnostic criteria of NMO proposed by Wingerchuk et al.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!