During early embryogenesis in amniotic vertebrates, the gonads differentiate into either ovaries or testes. The first cell lineage to differentiate gives rise to the supporting cells: Sertoli cells in males and pre-granulosa cells in females. These key cell types direct the differentiation of the other cell types in the gonad, including steroidogenic cells. The gonadal surface epithelium and the interstitial cell populations are less well studied, and little is known about their sexual differentiation programs. Here, we show the requirement of the homeobox transcription factor gene TGIF1 for ovarian development in the chicken embryo. TGIF1 is expressed in the two principal ovarian somatic cell populations: the cortex and the pre-granulosa cells of the medulla. TGIF1 expression is associated with an ovarian phenotype in estrogen-mediated sex reversal experiments. Targeted misexpression and gene knockdown indicate that TGIF1 is required, but not sufficient, for proper ovarian cortex formation. In addition, TGIF1 is identified as the first known regulator of juxtacortical medulla development. These findings provide new insights into chicken ovarian differentiation and development, specifically cortical and juxtacortical medulla formation.
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http://dx.doi.org/10.1242/dev.199646 | DOI Listing |
Front Neurol
August 2023
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Introduction: Ondine's curse is a rare respiratory disorder that is characterized by central alveolar hypoventilation (CAH) during sleep. It is most commonly congenital. However, it can also be acquired very rarely.
View Article and Find Full Text PDFIndian J Crit Care Med
January 2022
Department of Critical Care Medicine, Sir Ganga Ram Hospital, New Delhi, India.
Unlabelled: A 40-year-old woman known hypertensive presented with progressive ascending paralysis. MRI T2W and FLAIR screening of the brain demonstrated swelling with altered signal in the visual cervical cord, medulla, and another juxtacortical lesion in the right temporal lobe with possibility of a demyelinating etiology. CSF testing did not identify a direct cerebral infection.
View Article and Find Full Text PDFMult Scler Relat Disord
February 2022
Department of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Background: Exclusive emesis has been observed in few patients of MOG-associated disorder (MOGAD).
Objectives: To study the occurrence of emesis in patients of Demyelinating disorders and determine their clinical and radiological features.
Methods And Results: Medical records of 551 patients of CNS demyelinating disorders were reviewed.
Development
August 2021
Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia.
During early embryogenesis in amniotic vertebrates, the gonads differentiate into either ovaries or testes. The first cell lineage to differentiate gives rise to the supporting cells: Sertoli cells in males and pre-granulosa cells in females. These key cell types direct the differentiation of the other cell types in the gonad, including steroidogenic cells.
View Article and Find Full Text PDFActa Neurol Scand
October 2008
Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Objective: Brain abnormalities in neuromyelitis optica (NMO) attracted much attention. Our study was to identify the brain magnetic resonance imaging (MRI) abnormalities in Chinese NMO patients.
Methods: Patients who fulfilled the latest diagnostic criteria of NMO proposed by Wingerchuk et al.
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