Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.

We aimed to evaluate the diagnostic and prognostic values of in breast cancer (BC) patients. Kaplan-Meier plotter was used to evaluate the prognostic values of  and correlations between their expression and clinical characteristics were assessed based on The Cancer Genome Atlas and the Human Protein Atlas. The current study showed that P4HAs were highly expressed in BC patients with clinical stage I compared with nontumor control and elevated were correlated with poor survival outcomes. Subtypes analysis revealed that and were most expressed in HER2+ subtypes patients. Univariate analysis displayed that elevated and correlated with unfavorable recurrence-free survival in mutated patients. This study indicated the diagnostic and prognostic roles of members and broadened the biomarker fields of early diagnosis and prognostic monitoring of BC patients.