Basaloid follicular hamartoma (BFH) is a rare follicular hamartoma of benign nature, which should be part of the differential diagnoses of basal cell carcinoma. Familial multiple BFH (FMBFH) is a hereditary subtype which typically presents early in life with multiple small, skin-colored papules primarily on the central face. Although these lesions are usually asymptomatic, they can be cosmetically disfiguring. Treatment options include surgery, cryotherapy, CO2 laser and imiquimod; no standard of care has been determined. We present a case of FMBFH presenting in adulthood, which was treated with CO2 laser with satisfactory results.
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http://dx.doi.org/10.5070/D327654066 | DOI Listing |
Dermatol Reports
September 2024
Institute for Research in Biomedical Sciences, Faculty of Human Medicine, Ricardo Palma University, Lima.
The skin covers our body and exhibits a complex structure that is adapted to the different body areas. The scalp skin is distinctive, and the histopathological alterations in its diseases also present distinctive features. We present the clinical case of a 28-year-old female patient, with no significant medical history.
View Article and Find Full Text PDFPathology
September 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France; CARADERM Network, France; 'Biologie des infections à polyomavirus' Team, UMR INRA ISP 1282, Université de Tours, Tours, France.
Genes (Basel)
September 2024
Medical Oncology Department, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain.
Cancer Res
November 2024
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Patients with PTEN hamartoma tumor syndrome (PHTS), a molecular diagnosis for those carrying germline PTEN pathogenic variants, have a high prevalence of benign and malignant thyroid disease. Characterizing the genomic landscape in PHTS thyroid tumors could provide insights into malignant potential and tumor progression to help optimize diagnosis, surveillance, and treatment in this population. To reveal the somatic alterations in PHTS-associated thyroid tumors, we conducted exome sequencing on 58 thyroid tumors (28 cancers, 30 benign nodules) from 19 patients with PHTS.
View Article and Find Full Text PDFJAMA Dermatol
November 2024
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
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