Nanoformulations of mononuclear Pt complexes cis-PtCl (PPh ) (1), [Pt(PPh ) (L-Cys)] ⋅ H O (3, L-Cys=L-cysteinate), trans-PtCl (PPh PhNMe ) (4; PPh PhNMe =4-(dimethylamine)triphenylphosphine), trans-PtI (PPh PhNMe ) (5) and dinuclear Pt cluster Pt (μ-S) (PPh ) (2) have comparable cytotoxicity to cisplatin against murine melanoma cell line B16F10. Masking of these discrete molecular entities within the hydrophobic core of Pluronic® F-127 significantly boosted their solubility and stability, ensuring efficient cellular uptake, giving in vitro IC values in the range of 0.87-11.23 μM. These results highlight the potential therapeutic value of Pt complexes featuring stable Pt-P bonds in nanocomposite formulations with biocompatible amphiphilic polymers.
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