AI Article Synopsis
- Thirteen new diterpenoid quinones were extracted from the dried roots of the plant Salvia miltiorrhiza, and their structures were identified using advanced analytical methods like NMR and X-ray diffraction.* -
- The absolute configurations of these compounds were confirmed through techniques such as circular dichroism spectroscopy and optical rotation.* -
- Among these compounds, salviadionether and other derivatives demonstrated significant anti-cancer properties, particularly salviadionether, which inhibited the growth of specific tumor cells, and salvianone ester A, which was strongly cytotoxic to tumor-repopulating cells.*
Article Abstract
Thirteen undescribed diterpenoid quinones were isolated from the dried roots of Salvia miltiorrhiza. Their structures were determined by extensive analysis, including NMR, HRESIMS, and IR. Their absolute configurations were determined by X-ray diffraction, calculated and experimental circular dichroism spectroscopy, and optical rotation. In the evaluation of bioactivities, salviadionether obviously inhibited the proliferation of HCT-116 cells. R-(+)-salmiltiorin E and R-(+)-grandifolia D both showed inhibitory activities on a variety of tumor cells. Salvianone ester A showed strong cytotoxicity to tumor-repopulating cells (TRCs) with an IC value of 2.19 μM.
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| http://dx.doi.org/10.1016/j.phytochem.2021.112902 | DOI Listing |
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