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Nonalcoholic fatty liver disease stratification by liver lipidomics. | LitMetric

AI Article Synopsis

  • Nonalcoholic fatty liver disease (NAFLD) is a condition that makes the liver store too much fat, which can cause problems for people's health.
  • Scientists studied liver samples from 365 patients to find out how different types of fats (lipids) change in the liver when someone has NAFLD.
  • They discovered that specific kinds of fat called sphingomyelins can help tell apart different stages of the disease and could be used to identify early and advanced NAFLD.

Article Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly understood. Using high-resolution shotgun mass spectrometry, we quantified the molar abundance of 316 species from 22 major lipid classes in liver biopsies of 365 patients, including nonsteatotic patients with normal or excessive weight, patients diagnosed with NAFL (nonalcoholic fatty liver) or NASH (nonalcoholic steatohepatitis), and patients bearing common mutations of NAFLD-related protein factors. We confirmed the progressive accumulation of di- and triacylglycerols and cholesteryl esters in the liver of NAFL and NASH patients, while the bulk composition of glycerophospho- and sphingolipids remained unchanged. Further stratification by biclustering analysis identified sphingomyelin species comprising n24:2 fatty acid moieties as membrane lipid markers of NAFLD. Normalized relative abundance of sphingomyelins SM 43:3;2 and SM 43:1;2 containing n24:2 and n24:0 fatty acid moieties, respectively, showed opposite trends during NAFLD progression and distinguished NAFL and NASH lipidomes from the lipidome of nonsteatotic livers. Together with several glycerophospholipids containing a C22:6 fatty acid moiety, these lipids serve as markers of early and advanced stages of NAFL.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488246PMC
http://dx.doi.org/10.1016/j.jlr.2021.100104DOI Listing

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