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Successful Laparoscopy-Assisted Extirpation of Burkitt's Lymphoma Causing Intestinal Obstruction in a 17-Year-Old Boy.
J Clin Med
December 2024
Department of Pediatric Surgery and Orthopedics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, Romania.
Childhood extranodal B-cell non-Hodgkin's lymphomas are often caused by Burkitt's lymphoma (BL). Treatment usually involves intensive polychemotherapy, and recent prospective trials show significantly improved outcomes. Surgery primarily involves conducting biopsies; ablative interventions are not recommended.
View Article and Find Full Text PDFImmunodeficiency-related high-grade B-cell lymphoma with 11q aberration: Further evidence for a lymphoma entity from a patient with simultaneous papillary renal cell carcinoma following pediatric kidney transplant.
Pathol Res Pract
December 2024
Section of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy. Electronic address:
Various aggressive lymphomas entities have been associated with immunodeficiency. To provide further evidence that also MYC-negative high-grade B-cell (formerly Burkitt-like) lymphoma with 11q aberrations comprises an immunodeficiency-related subtype, we here conducted a comprehensive pathological and genetic workup of a 25-year-old patient with this type of lymphoma and simultaneous papillary renal cell carcinoma. The patient developed both malignancies following extensive childhood immunosuppression and a kidney transplant.
View Article and Find Full Text PDFKi-67 as a Marker to Differentiate Burkitt Lymphoma and Diffuse Large B-cell Lymphoma: A Literature Review.
Cureus
October 2024
Clinical Pathology, Sebelas Maret University, Solo, IDN.
Article Synopsis
- Burkitt lymphoma (BL) is a highly aggressive type of non-Hodgkin's lymphoma primarily affecting children, comprising 40% of childhood NHL, while it's less common in adults.
- Diffuse large B-cell lymphoma (DLBCL) is the most prevalent lymphoma, accounting for roughly 25% of NHL cases worldwide, and distinguishing between BL and DLBCL is crucial for determining appropriate treatments.
- This article investigates the role of the Ki-67 marker, which shows significantly higher levels in BL (close to 100%) compared to DLBCL (40% to 90%), as a means to differentiate between these two types of lymphoma.
Association Between Perinatal Factors and Childhood Lymphoma-A Pooled Analysis of the ESCALE and ESTELLE Studies (SFCE).
Pediatr Blood Cancer
February 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Epidemiology of Childhood And Adolescent Cancer (EPICEA) team, Paris, France.
Article Synopsis
- The study investigates the link between pregnancy-related factors and the risk of childhood lymphoma, focusing on non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) in a large French case-control analysis.
- Results indicate that maternal coffee and alcohol consumption during pregnancy, as well as paternal smoking, are associated with an increased risk of childhood NHL, with a dose-response relation seen in coffee intake.
- The research suggests that understanding these associations can improve knowledge of childhood lymphoma aetiology, although further studies are needed to confirm these findings.
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