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A Case of Acquired Methemoglobinemia Following Sentinel Lymph Node Dye With Patent Blue V.
Cureus
November 2024
Department of Anesthesiology and Intensive Care, Celal Bayar University Training and Research Hospital, Manisa, TUR.
Methemoglobinemia is a rare but potentially life-threatening condition in which hemoglobin is oxidized, impairing the oxygen-carrying capacity. While congenital forms exist, acquired methemoglobinemia can occur in perioperative settings, especially following exposure to oxidizing agents such as dyes used in sentinel lymph node biopsy (SLNB). Patent Blue V, a synthetic aniline dye commonly used for SLNB, has been associated with rare but serious adverse effects, including methemoglobinemia.
View Article and Find Full Text PDFHydroxocobalamin is not associated with methemoglobinemia in patients with inhalation injury and suspected cyanide toxicity and a proposed algorithm for hydroxocobalamin administration.
Burns
September 2024
Department of Plastic and Reconstructive Surgery, University of Southern California, Los Angeles, CA, USA; Department of Surgery, Los Angeles General Medical Center, Los Angeles, CA, USA. Electronic address:
Background: Cyanide poisoning poses a significant threat to burn patients exposed to smoke in residential or workplace fires, leading to central nervous system dysfunction, hemodynamic instability, cardiovascular collapse, and death. Prompt administration of an effective antidote is critical. Hydroxocobalamin, a form of vitamin B12, is the gold standard treatment for cyanide toxicity, by binding to cyanide molecules and converting them into non-toxic cyanocobalamin that is eliminated by the kidneys.
View Article and Find Full Text PDF[Sulfhemoglobinemia secondary to the use of zopiclone. Report of two cases].
Rev Med Chil
October 2022
Sección de Hematología, Servicio de Medicina, Hospital del Salvador, Santiago, Chile.
Article Synopsis
- Sulfhemoglobin (SulfHb) is a compound formed when hemoglobin is oxidized by sulfur compounds, often linked to drug use or bacterial overgrowth in the intestines, and presents as cyanosis with normal oxygen levels in the blood.
- A case study reported two women with cyanosis after high doses of zopiclone, where typical diagnoses like methemoglobinemia were ruled out, complicating the confirmation of sulfhemoglobinemia due to interference with co-oximetry tests.
- Although sulfhemoglobinemia is usually self-limiting and confirmatory tests are scarce in Chile, it is crucial to distinguish it from methemoglobinemia to prevent unnecessary treatments.
Elevated methemoglobin levels in patients treated with high-dose hydroxocobalamin.
Lab Med
January 2024
Memorial Cardiac & Vascular Institute, Memorial Healthcare System, Hollywood, FL, US.
Objective: The aim of this study was to assess the impact of hydroxocobalamin (OHCbl) infusion on arterial blood gas and oximetry values in patients with vasoplegic syndrome.
Methods: Blood samples collected from 95 patients receiving OHCbl infusion were assayed using the ABL90 FLEX Plus blood gas analyzer for the concentration of methemoglobin (MetHb), total hemoglobin (tHb), carboxyhemoglobin (COHb), arterial oxygen saturation (SaO2), arterial oxygen partial pressure (PaO2), and arterial carbon dioxide partial pressure (PaCO2). Interference of OHCbl on these variables was evaluated using the measured difference between the preinfusion and postinfusion samples.
Sample stability and heparin interference in ionized calcium and ionized magnesium measurements in horses using the Stat Profile Prime Plus co-oximetry electrolyte analyzer.
Vet Clin Pathol
June 2023
Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.
Background: The determination of iCa and iMg is important in veterinary medicine, but their immediate determination in whole blood is not always possible. Their stability in other sample types and the existence of interferences must be evaluated before its use.
Objectives: We aimed to analyze the effects of storage time on the stability of iCa, iMg, and other analytes in whole blood, plasma, and serum samples in horses and assess the interference of heparin in these measurements.
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