[Clinico-genealogical study of microcirculation in diabetes mellitus type 1].

Altogether 60 patients with type I diabetes mellitus and their 29 relatives were examined. Diabetic microangiopathies were diagnosed in 29 patients, in 31 they were not found. Among relatives of the 1st degree of relationship 16 persons were with type I diabetes mellitus with angiopathies, 13 persons without angiopathies. In the patients with microangiopathies a degree of platelet aggregation significantly exceeded a similar index in the patients without microangiopathies in all age groups. In the relatives of the patients with diabetes mellitus complicated by microangiopathies, a degree of platelet aggregation was significantly higher than that in the relatives of the patients with diabetes mellitus without microangiopathies. It suggests hereditary predisposition to the development of diabetic microangiopathies. In the patients with microangiopathies there was an increase in the level of pre-beta-fraction and a decrease in the level of alpha-fraction of lipoproteins suggesting interrelationship of rheological disorders and lipid metabolism.